Domitilla de Martino (INAF-AO Capodimonte Naples) - LOFT Observatory Science: Accreting White Dwarf binaries Accreting white dwarf binaries display a wide range of temporal variabilities. LOFT will be particularly suited to explore fast-to-moderate time variations of different subtypes of systems over a wide energy range and to monitor long term X-ray variations. Examples of open issues that LOFT can address will be given.